A 11 year-old boy with diffuse intrinsic pontine glioma (DIPG)…

Cancer History:

First diagnosis of cancer: 12/2018  cancer type: midline glioblastoma; stage IV

Refractory or persistent disease sites: Pons

Therapy gone through: Surgery: Yes (with residual)

Chemotherapy 2 cycles temozolomide regimen; radiotherapy: Yes (5400cGy/30f/41d)

Targeted drugs: no  immunotherapy: no others: no

Clinical Trial Number: NCT03170141; enrolled date: 24/04/2019

Interventions: CART (GD2, PSMA) after lymphodepletion with Flu-Cy

CRS Grade: 1 ; other side effects: no

Treatment response: CR (after CAR-T infusion 36 days)

Quality of Life: Improved

Current status: No evidence of disease

Disease images before and after CART treatment